| Autor: |
Satoru, Kaifuchi, Mihoko, Mori, Kenichi, Nonaka, Rokuro, Masuma, Satoshi, Ōmura, Kazuro, Shiomi |
| Rok vydání: |
2015 |
| Předmět: |
|
| Zdroj: |
The Journal of general and applied microbiology. 61(2) |
| ISSN: |
1349-8037 |
| Popis: |
Screening for NADH-fumarate reductase inhibitors led to the isolation of a new ukulactone analog, ukulactone C, as a major polyene compound produced by Talaromyces sp. FKI-6713. The structure of the compound was elucidated as a reduced analog of ukulactone A by 1D- and 2D-NMR experiments. Ukulactone C possessed a potent inhibitory activity (IC(50) = 62 nM) against NADH-fumarate reductase of the roundworm Ascaris suum in vitro. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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