| Autor: |
C S, Rosenfeld, W B, Rybka, D, Weinbaum, D R, Carrigan, K K, Knox, D F, Andrews, R K, Shadduck |
| Rok vydání: |
1995 |
| Předmět: |
|
| Zdroj: |
Experimental hematology. 23(7) |
| ISSN: |
0301-472X |
| Popis: |
Hematopoietic effects of human Herpesvirus-6 (HHV-6) infection following bone marrow transplantation (BMT) include delayed engraftment and early myelosuppression. Variant A has not been isolated after BMT. A case of graft failure is reported following an HLA-identical BMT for chronic myelogenous leukemia (CML) in chronic phase. Evaluation of bone marrow during the period of graft failure revealed variants A and B of HHV-6 by culture, immunofluorescence, polymerase chain reaction (PCR), and immunohistochemistry. Evidence for other cases of graft failure, including cytomegalovirus (CMV), could not be found. A hypothesis is proposed that late graft failure in this case was due to variant A of HHV-6. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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