Colonic overexpression of the T-type calcium channel Ca

Autor:	J, Scanzi, A, Accarie, E, Muller, B, Pereira, Y, Aissouni, M, Goutte, J, Joubert-Zakeyh, E, Picard, L, Boudieu, C, Mallet, A, Gelot, D, Ardid, F A, Carvalho, M, Dapoigny
Rok vydání:	2015
Předmět:	Male Mice Knockout Colon Gene Expression Visceral Pain Middle Aged Irritable Bowel Syndrome Mice Inbred C57BL Calcium Channels T-Type Disease Models Animal Mice Animals Humans Female Intestinal Mucosa
Zdroj:	Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society. 28(11)
ISSN:	1365-2982
Popis:	Among the different mechanisms involved in irritable bowel syndrome (IBS) physiopathology, visceral hypersensitivity seems to play a key role. It involves sensitization of the colonic primary afferent fibers, especially through an overexpression of ion channels. The aims of this translational study were to investigate the colonic expression of CaThis bench-to-bed study combined a preclinical experimental study on mice and a case-control clinical study. Preclinical studies were performed on wild-type and CaWild-type, but not CaThis translational study supports the involvement of the calcium channels Ca
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::146da279d1af7b88e07697bf4f2b916c https://pubmed.ncbi.nlm.nih.gov/27196538 Zobrazit plný text záznamu Plný text