T cells in the pathogenesis of ANCA-associated vasculitis: current knowledge

Autor: Z, Hrusková, H, Marecková, Z, Ríhová, R, Rysavá, E, Jancová, M, Merta, V, Tesar
Rok vydání: 2008
Předmět:
Zdroj: Folia biologica. 54(3)
ISSN: 0015-5500
Popis: AAV are a group of systemic immune-mediated diseases with a strong and highly specific association with ANCA. In recent years, there has been increasing evidence that ANCA might play a direct pathogenic role in triggering AAV. Nevertheless, effectors of cell-mediated immunity prevail in the inflammation sites in patients with AAV. Numerous studies found increased markers of T-cell activation in AAV. Moreover, this activation persisted even in remission and despite treatment. Finally, successful therapeutic attempts using T cell-directed treatment were also reported. There has therefore been substantial evidence that T cells are involved in the pathogenesis of AAV, even though the exact mechanisms are yet to be elucidated. In this review, recent findings on the contribution of T cells to the pathogenic processes in AAV will be briefly summarized. Special emphasis will be placed on the Th1/Th2 concept, the role of T-regulatory cells, and the role of effector memory T cells in the pathogenesis of AAV.
Databáze: OpenAIRE
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