HLA frequencies and associations in cystic fibrosis

Autor:	M P M, Adriaanse, A C E, Vreugdenhil, M, Groeneweg, H T, Brüggenwirth, S J A M, Castelijns, C K, van der Ent, C E M, Voorter, M G J, Tilanus
Rok vydání:	2013
Předmět:	Male Polymorphism Genetic Cystic Fibrosis Gene Frequency Genotype HLA Antigens DNA Mutational Analysis Cystic Fibrosis Transmembrane Conductance Regulator Humans Female Genetic Predisposition to Disease Genetic Association Studies
Zdroj:	Tissue antigens. 83(1)
ISSN:	1399-0039
Popis:	Cystic fibrosis (CF) is classically attributed to the dysfunction of the single CF transmembrane conductance regulator gene. The incidence of human leukocyte antigen (HLA) polymorphisms in different CF-associated diseases raises the question of an unequal distribution of HLA genotypes in CF. This study aimed to evaluate HLA gene frequencies and possible associations in CF patients compared with a control population. Frequencies of HLA-DRB1, HLA-DQA1 and HLA-DQB1, performed by intermediate resolution typing using Luminex sequence-specific oligonucleotide, and epitope counts were similar in 340 CF patients when compared with 400 control subjects. In conclusion, HLA-DRB1, -DQA1 and -DQB1 do not seem to influence susceptibility to CF. Whether HLA plays a role in the severity of CF disease needs to be investigated.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::144ff91a58044c1a9b2b2b8274c8446f https://pubmed.ncbi.nlm.nih.gov/24355005 Zobrazit plný text záznamu Plný text