| Autor: |
Luscombe, M., Poulding, J. M., Amer, B., Clamp, J. R., Hartog, M., Shelley, J. H., Tribe, C. R. |
| Jazyk: |
angličtina |
| Rok vydání: |
1983 |
| Předmět: |
|
| Popis: |
Diabetes was induced in male Wistar rats by a single i.v. injection of streptozotocin (40 mg/kg). Animals were treated with bromhexine at 2 dose levels (2.5 mg/kg/day and 25 mg/kg/day) for 13 months thereafter and compared to non-diabetic controls and untreated diabetic animals. Renal pathology showed a significant increase in glomerular volume and basement membrane thickening in untreated diabetic animals. The higher dose bromhexine treated diabetic animals showed a significant decrease in glomerular volume as compared with diabetic animals not given bromhexine. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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