[Effects of quercetin on the expression of VEGF-C and VEGFR-3 in human cancer MGC-803 cells]

Autor: Zhi-jun, Yu, Li-ya, He, Yong, Chen, Mian-yun, Wu, Xue-hua, Zhao, Zhen-yu, Wang
Rok vydání: 2009
Předmět:
Zdroj: Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. 25(8)
ISSN: 1007-8738
Popis: To investigate the mechanism of quercetin on the inhibition of the lymphatic metastasis in human gastric cancer cells MGC-803.Cells were divided into the control group and the quercetin (Que)-treated group. Immunohistochemistry and RT-PCR were used to detect the expression of vascular endothelial growth factor C (VEGF-C) and VEGFR-3 of human gastric cancer cells MGC-803 in response to Que.Que significantly decreased the expression of VEGF-C and VEGFR-3 at 40 mumol/L compared with the control group after 48 h (P0.01).Que can down-regulate the expression of VEGF-C and VEGFR-3 in human gastric cancer cells MGC-803.
Databáze: OpenAIRE