| Autor: |
Mary C, Cambou, Christine M, Liu, Thalia, Mok, Viviana, Fajardo-Martinez, Sophia G, Paiola, Francisco J, Ibarrondo, Tara, Kerin, Trevon, Fuller, Nicole H, Tobin, Gustavo, Garcia Jr., Debika, Bhattacharya, Grace M, Aldrovandi, Vaithilingaraja, Arumugaswami, Suan Sin, Foo, Jae U, Jung, Zilton, Vasconcelos, Patricia, Brasil, Michelle, Brendolin, Otto, O. Yang, Rashmi, Rao, Karin, Nielsen-Saines |
| Rok vydání: |
2022 |
| Zdroj: |
The Journal of infectious diseases. |
| ISSN: |
1537-6613 |
| Popis: |
There are limited data on how COVID-19 severity, timing of infection, and subsequent vaccination impact transplacental transfer and persistence of maternal and infant antibodies.In a longitudinal cohort of pregnant women with PCR-confirmed SARS-CoV-2 infection, maternal/infant sera were collected at enrollment, delivery/birth, and 6 months. Anti-SARS-CoV-2 spike IgG, IgM and IgA were measured by ELISA.256 pregnant women and 135 infants were enrolled; 148 maternal and 122 neonatal specimens were collected at delivery/birth; 45 maternal and 48 infant specimens were collected at 6 months. Sixty-eight percent of women produced all anti-SARS-CoV-2 isotypes at delivery (IgG, IgM, IgA); 96% had at least one isotype. Symptomatic disease, and vaccination prior to delivery, were associated with higher maternal IgG at LD. Detectable IgG in infants dropped from 78% at birth to 52% at 6 months. In the multivariate analysis evaluating factors associated with detectable IgG in infants at delivery, significant predictors were 3rd trimester infection (OR 4.0), mild/moderate disease (OR 4.8), severe/critical disease (OR 6.3), and maternal vaccination prior to delivery (OR 18.8). No factors were significant in the multivariate analysis at 6 months postpartum.Vaccination in pregnancy post-COVID-19 recovery is a strategy for boosting antibodies in mother-infant dyads. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
