| Autor: |
Maria, Loizou, Petri, Papaphilippou, Manolis, Vlasiou, Maria, Spilia, Dimitrios, Peschos, Yannis V, Simos, Anastasios D, Keramidas, Chryssoula, Drouza |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Journal of inorganic biochemistry. 235 |
| ISSN: |
1873-3344 |
| Popis: |
Since the discovery of the anticancer properties of cis-platin the road for the development of less toxic and more specific metal ion based anticancer drugs has opened. Based on the low toxicity of VsupIV/V/sup, MosupVI/supand ZnsupII/supmetal ions, their binuclear hydroquinonate complexes have been synthesized and their biological activity towards their anticancer properties on various cancerous and non-cancerous cell lines has been evaluated. The new complexes of ZnsupII/supwith the ligands 2,5-bis((bis(pyridin-2-ylmethyl)amino)methyl)benzene-1,4-diol (Hsub2/subbpymah) and 2,2'-(((2,5-dihydroxy-1,4-phenylene)bis(methylene))bis((carboxymethyl)ammoniumdiyl))diacetate (Hsub6/subbicah) have been synthesized and characterized by X-ray crystallography in solid state andsup1/supH NMR in aqueous solution. The binuclear nature of the complexes increases their hydrolytic stability in aqueous solutions at pD 7.0, depending on the metal ion. The most hydrolytic stable VsupV/supand ZnsupII/suphydroquinonate complexes show to activate Osub2/subtowards oxidation of mercaptoethanol in aqueous solutions at physiological pHs. Only the strongest oxidant, the VsupV/supcomplex with bicahsup6-/sup, significantly activates the intracellular radical oxygen species (ROS) generation. Apparently, the mercaptoethanol oxidation experiment vs time can be used as a preliminary experiment for the prediction of the in vitro ROS generation activity of the complexes in aqueous solutions. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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