| Autor: |
K L, Beemon, M M, O'Reilly, M R, Smith, R E, Smith, I, Dunkel, W S, Hayward |
| Rok vydání: |
1997 |
| Předmět: |
|
| Zdroj: |
Leukemia. 11 |
| ISSN: |
0887-6924 |
| Popis: |
Avian leukosis viruses (ALVs) that induce rapid B-cell lymphomas integrate into the c-myb gene and produce an ALV-myb read-through RNA, which is spliced to produce a truncated Myb protein. The genetic determinants of such recombinant ALVs have been mapped to a 42-nt deletion within the gag gene. This deletion increases splicing efficiency since it is located within a negative regulator of splicing. We propose that the deletion leads to increased production of Myb protein by increasing splicing of an ALV-myb pre-mRNA. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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