Preoperative values of CA 15-3 and CEA as prognostic factors in breast cancer: a multivariate analysis
| Autor: | F, Cañizares, J, Sola, M, Pérez, I, Tovar, M, De Las Heras, J, Salinas, R, Peñafiel, P, Martínez |
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| Rok vydání: | 2001 |
| Předmět: |
Adult
Cell Cycle Mucin-1 Breast Neoplasms DNA Neoplasm Middle Aged Aneuploidy Flow Cytometry Ornithine Decarboxylase Prognosis Diploidy Carcinoembryonic Antigen Survival Rate Necrosis Receptors Estrogen Recurrence Lymphatic Metastasis Multivariate Analysis Biomarkers Tumor Humans Female Menopause Receptors Progesterone Aged Retrospective Studies |
| Zdroj: | Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. 22(5) |
| ISSN: | 1010-4283 |
| Popis: | The role of circulating tumor markers in providing prognostic information has not been widely studied. In the current study, serum levels of the carbohydrate antigen 15-3 (CA 15-3) and carcinoembryonic antigen (CEA) were determined preoperatively in 364 breast cancer patients with no clinical signs of metastasis. The prognostic relevance of these markers for recurrence (175/364) and death of disease (104/175) was determined by Cox multivariate analysis, including the comparison with classical prognostic factors. High levels of both tumor markers were associated with aneuploid tumors with high S-phase fraction and high ornithine decarboxylase activity. CA 15-3 was highly associated with the number of positive lymph nodes and peritumoral lymphatic or blood vessel invasion. No significant associations were found between CEA or CA 15-3 levels and histologic grade, necrosis and steroid receptor status. In univariate analysis, preoperative values, using optimum cutoff values of CA 15-3 (40 U/ml) and CEA (6 ng/ml), were statistically significant for relapse-free survival and overall survival. In multivariate analysis, only node status, DNA ploidy and ornithine decarboxylase activity were independent predictors for relapse-free survival; the estrogen receptor status was a predictor of overall survival. In node-negative patients, ornithine decarboxylase activity was the only factor selected for relapse-free survival. In node-positive patients, the number of lymph nodes and DNA ploidy were the only variables selected for relapse-free survival or overall survival. Estrogen receptor and ornithine decarboxylase activity were excluded for relapse-free survival, but were significant prognostic factors for overall survival. |
| Databáze: | OpenAIRE |
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