Clinical effects and pharmacokinetic variables of romifidine and the peripheral α

Autor:	Annemarie, de Vries, Soile Ae, Pakkanen, Marja R, Raekallio, Abel, Ekiri, Mika, Scheinin, Polly M, Taylor, Outi M, Vainio
Rok vydání:	2015
Předmět:	Cross-Over Studies Respiration Imidazoles Cardiovascular System Anesthetics Combined Adrenergic alpha-2 Receptor Agonists Anesthesia Intravenous Animals Hypnotics and Sedatives Female Horses Blood Gas Analysis Deep Sedation Quinolizines
Zdroj:	Veterinary anaesthesia and analgesia. 43(6)
ISSN:	1467-2995
Popis:	To investigate the effects of MK-467 on sedation quality, and cardiopulmonary and pharmacokinetic variables in horses sedated intravenously (IV) with romifidine.Experimental, randomized, crossover design.Seven healthy mares.Romifidine (80 μg kgAfter R, ABP increased and HR and fCombined romifidine and MK-467 prevented the cardiovascular changes commonly seen with romifidine but did not affect sedation quality.Combined IV romifidine and MK-467 can be used to attenuate the cardiovascular effects of romifidine, such as in horses with colic or undergoing general anaesthesia.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::13ea11c01739de7be3ca695cb6f4a97b https://pubmed.ncbi.nlm.nih.gov/26918855 Zobrazit plný text záznamu Plný text