High impact of macroaggregated albumin-based tumour dose on response and overall survival in hepatocellular carcinoma patients treated with
| Autor: | Etienne, Garin, Yan, Rolland, Marc, Pracht, Samuel, Le Sourd, Sophie, Laffont, Habiba, Mesbah, Laure-Anne, Haumont, Laurence, Lenoir, Tanguy, Rohou, Vanessa, Brun, Julien, Edeline |
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| Rok vydání: | 2016 |
| Předmět: |
Male
Venous Thrombosis Carcinoma Hepatocellular Portal Vein Liver Neoplasms Kaplan-Meier Estimate Middle Aged Embolization Therapeutic Microspheres Logistic Models Multivariate Analysis Humans Female Yttrium Radioisotopes France Prospective Studies Radiopharmaceuticals Tomography X-Ray Computed Technetium Tc 99m Aggregated Albumin Aged Proportional Hazards Models |
| Zdroj: | Liver international : official journal of the International Association for the Study of the Liver. 37(1) |
| ISSN: | 1478-3231 |
| Popis: | Efficacy of radioembolization is derived from radioinduced damage, whereas tumour dosimetry is not considered as yet in prospective clinical trials.This study evaluates the impact of tumour dose (TD), based onWe consecutively included 85 patients with hepatocellular carcinoma treated withResponse rate was 80.3% on lesion-based analysis (n=132), and 77.5% on patient-based analysis. The response rate was only 9.1% for patients with TD205 Gy against 89.7% for those with TD ≥205 Gy (P10This study confirms the highly predictive value of MAA-based TD evaluation for response and OS. TD evaluation and PVT MAA targeting should be further evaluated in ongoing trials, whereas personalized dosimetry should be implemented in new trial designs. |
| Databáze: | OpenAIRE |
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