Graft-induced dyskinesias in Parkinson's disease: High striatal serotonin/dopamine transporter ratio
| Autor: | Marios, Politis, Wolfgang H, Oertel, Kit, Wu, Niall P, Quinn, Oliver, Pogarell, David J, Brooks, Anders, Bjorklund, Olle, Lindvall, Paola, Piccini |
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| Rok vydání: | 2011 |
| Předmět: |
Male
Serotonin Plasma Membrane Transport Proteins Tomography Emission-Computed Single-Photon Brain Mapping Dopamine Plasma Membrane Transport Proteins Dyskinesias Time Factors Parkinson Disease Middle Aged Corpus Striatum Functional Laterality Dihydroxyphenylalanine Positron-Emission Tomography Humans Brain Tissue Transplantation Longitudinal Studies Tropanes |
| Zdroj: | Movement disorders : official journal of the Movement Disorder Society. 26(11) |
| ISSN: | 1531-8257 |
| Popis: | Graft-induced dyskinesias are a serious complication after neural transplantation in Parkinson's disease. One patient with Parkinson's disease, treated with fetal grafts 14 years ago and deep brain stimulation 6 years ago, showed marked improvement of motor symptoms but continued to suffer from OFF-medication graft-induced dyskinesias. The patient received a series of clinical and imaging assessments. Positron emission tomography and single-photon emission computed tomography 14 years posttransplantation revealed an elevated serotonin/dopamine transporter ratio in the grafted striatum compatible with serotonergic hyperinnervation. Inhibition of serotonin neuron activity by systemic administration of a 5-HT(1A) agonist suppressed graft-induced dyskinesias. Our data provide further evidence that serotonergic neurons mediate graft-induced dyskinesias in Parkinson's disease. Achieving a normal striatal serotonin/dopamine transporter ratio following transplantation of fetal tissue or stem cells should be necessary to avoid the development of graft-induced dyskinesias. |
| Databáze: | OpenAIRE |
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