Role of Bacterial Infection in the Development of Acute Liver Failure in Patients with Decompensated Alcoholic Liver Cirrhosis
| Autor: | A S, Rodina, M E, Shubina, I V, Kurbatova, O P, Dudanova |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Adult
Male Keratin-18 Interleukin-6 Tumor Necrosis Factor-alpha Interleukin-1beta Interleukin-8 Acute-On-Chronic Liver Failure Bacterial Infections Middle Aged Prognosis Severity of Illness Index Survival Analysis Liver Liver Cirrhosis Alcoholic Case-Control Studies Humans Female Aspartate Aminotransferases Interleukin-4 Biomarkers |
| Zdroj: | Bulletin of experimental biology and medicine. 171(3) |
| ISSN: | 1573-8221 |
| Popis: | We examined 74 patients with acute decompensation of alcoholic liver cirrhosis: 34 (45.9%) with bacterial infection (group 1) and 40 (54.1%) without bacterial infection (group 2). The degree and index of acute-on-chronic liver failure (ACLF) were determined using an on-line CLIF-C ACLF Calculator and the levels of cytokeratin-18 fragments, TNFα, IL-1β, IL-4, IL-6, and IL-8. In group 1, AST, cytokeratin-18, TNFα, IL-1β, IL-6, degree and score of ACLF were significantly higher than in group 2. ACLF developed in 18 (52.9%) patients in group 1 and in 11 (27.5%) (p0.05) patients in group 2. Within 1 month, 10 (29.4%) patients of group 1 and 2 (5%) patients of group 2 died (p0.05). Patients with bacterial infection showed a more severe course of alcoholic liver cirrhosis and ACLF than those without bacterial infection. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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