| Autor: |
V N, Perfilova, N V, Sadikova, V M, Berestovitskaia, O S, Vasil'eva |
| Rok vydání: |
2014 |
| Předmět: |
|
| Zdroj: |
Eksperimental'naia i klinicheskaia farmakologiia. 77(9) |
| ISSN: |
0869-2092 |
| Popis: |
The effect of new glutamic acid derivative on the cardiac ino- and chronotropic functions has been studied in experiments on rats exposed to 24-hour immobilization-and-pain stress. It is established that glutamic acid derivative RGPU-238 (glufimet) at a dose of 28.7 mg/kg increases the increment of myocardial contractility and relaxation rates and left ventricular pressure in stress-tested animals by 13 1,1, 72.4, and 118.6%, respectively, as compared to the control group during the test for adrenoreactivity. Compound RGPU-238 increases the increment of the maximum intensity of myocardium functioning by 196.5 % at 30 sec of isometric workload as compared to the control group. The cardioprotective effect of compound RGPU-238 is 1.5 - 2 times higher than that of the reference drug phenibut. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
