Coenzyme AdoB12 vs AdoB12.-homolytic Co-C cleavage following electron transfer: a rate enhancement greater than or equal to 10(12)

Autor:	R G, Finke, B D, Martin
Rok vydání:	1990
Předmět:	Electron Transport Kinetics Vitamin B 12 Cobamides
Zdroj:	Journal of inorganic biochemistry. 40(1)
ISSN:	0162-0134
Popis:	Comparison of the 25 degrees C Co-C bond homolysis rate constant of adenosyl-cobalamin (coenzyme B12) vs that for electrochemically reduced adenosyl-cobalamin radical anion indicates a rate enhancement of at least 10(12 +/- 2) upon the addition of one antibonding electron. Even though electrochemical reduction promotes Co-C homolysis by virtually the same amount as the 10(12 +/- 1) enzymic activation seen for adenosylcobalamin, electron-transfer activation of the Co-C homolysis in adenosylcobalamin-dependent enzyme reactions is considered unlikely, based on four lines of evidence.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::1317df864df943f009c9dc895e8c0b99 https://pubmed.ncbi.nlm.nih.gov/2283507 Zobrazit plný text záznamu