Usefulness of pleural complement activation products in differentiating tuberculosis and malignant effusions
| Autor: | J M, Porcel, M, Vives, I, Gázquez, M C, Vicente de Vera, B, Pérez, M, Rubio |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Adult
Male Anaphylatoxins Enzyme-Linked Immunosorbent Assay Pilot Projects Complement Membrane Attack Complex Complement System Proteins Tuberculosis Pleural Pleural Effusion Malignant Diagnosis Differential Pleural Effusion Logistic Models ROC Curve Multivariate Analysis Complement C3a Humans Female Prospective Studies Glycoproteins |
| Zdroj: | The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease. 4(1) |
| ISSN: | 1027-3719 |
| Popis: | To determine whether measurement of the complement activation products SC5b-9 and C3a-desArg in pleural fluid can reliably differentiate tuberculous from malignant pleural effusions.Twenty-four patients with tuberculous pleuritis, 29 with malignant pleural effusion, and 30 control subjects with transudates were enrolled in the study. SCSb-9 and C3a-desArg were measured in pleural fluid using commercial ELISA tests, and their performances were evaluated using receiver operating characteristic (ROC) analysis.Patients with tuberculous pleuritis had higher mean levels of pleural SC5b-9 (5052 microg/L) and C3a-desArg (7436 microg/L) than those with malignant effusions (1048 and 2835 microg/L, respectively), whereas only SC5b-9 concentrations in the latter were comparable with controls. The area under the ROC curve (AUC) was 0.84 for SC5b-9 and 0.81 for C3a-desArg. Pleural SC5b-9 showed an accuracy of 80.8%, compared with 78.8% for C3a-desArg, when cut-off points of 1500 and 4500 microg/L, respectively, were used. Using a stepwise logistic regression model, the combination of pleural SCSb-9or =1500 microg/L, ageor =35 years, and pleural monocyte percentageor =90% provided the highest accuracy for tuberculous pleurisy (88.5%, AUC 0.95).This pilot study suggests that pleural SC5b-9 is clinically useful for differentiating tuberculous and malignant pleural effusions. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|