| Autor: |
R, Hernández-Alcoceba, F, Fernández, J C, Lacal |
| Rok vydání: |
1999 |
| Předmět: |
|
| Zdroj: |
Cancer research. 59(13) |
| ISSN: |
0008-5472 |
| Popis: |
Transformation by some oncogenes is associated with increased activity of choline kinase (ChoK), resulting in elevated constitutive levels of phosphorylcholine, a proposed second messenger required for DNA synthesis induced by growth factors. Here we describe the characterization of ChoK inhibitors with antiproliferative properties against human tumor-derived cell lines. The new molecules were tolerated in mice at doses that showed in vivo antitumor activity against human tumor xenografts derived from HT-29 and A431 cell lines implanted s.c. in nude mice. This first generation of inhibitors provides in vivo evidence that blockade of phosphorylcholine production is a valid strategy for the development of new anticancer agents, opening a new avenue for the development of antitumor drugs with a novel mechanism of action. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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