End stage liver disease etiology & transplantation referral outcomes of major ethnic groups in British Columbia, Canada
| Autor: | Chahal, Daljeet, Marquez, Vladimir, Hussaini, Trana, Kim, Peter, Chung, Stephen W., Segedi, Maja, Chartier-Plante, Stephanie, Scudamore, Charles H., Erb, Siegfried R., Salh, Baljinder, Yoshida, Eric M. |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Adult
Male Time Factors Waiting Lists etiology waitlist Observational Study Severity of Illness Index Body Mass Index End Stage Liver Disease Risk Factors Ethnicity Humans Referral and Consultation Aged British Columbia alcohol primary biliary cholangitis cirrhosis Age Factors primary sclerosing cholangitis Middle Aged Liver Transplantation liver transplant disparity Socioeconomic Factors epidemiology Female liver disease Research Article |
| Zdroj: | Medicine |
| ISSN: | 1536-5964 0025-7974 |
| Popis: | Liver disease etiology and transplantation outcomes may vary by ethnicity. We aimed to determine if disparities exist in our province. We reviewed the provincial database for liver transplant referrals. We stratified cohorts by ethnicity and analyzed disease etiology and outcomes. Four thousand nine hundred sixteen referrals included 220 South Asians, 413 Asians, 235 First Nations (Indigenous), and 2725 Caucasians. Predominant etiologies by ethnicity included alcohol (27.4%) and primary sclerosing cholangitis (PSC) (8.8%) in South Asians, hepatitis B (45.5%) and malignancy (13.9%) in Asians, primary biliary cholangitis (PBC) (33.2%) and autoimmune hepatitis (AIH) (10.8%) in First Nations, and hepatitis C (35.9%) in Caucasians. First Nations had lowest rate of transplantation (30.6%, P = .01) and highest rate of waitlist death (10.6%, P = .03). Median time from referral to transplantation (268 days) did not differ between ethnicities (P = .47). Likelihood of transplantation increased with lower body mass index (BMI) (hazard ratio [HR] 0.99, P = .03), higher model for end stage liver disease (MELD) (HR 1.02, P |
| Databáze: | OpenAIRE |
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