| Autor: |
Saurov, Mahanta, Tufan, Naiya, Kunal, Biswas, Liza, Changkakoti, Yugal Kishore, Mohanta, Bhaben, Tanti, Awdhesh Kumar, Mishra, Tapan Kumar, Mohanta, Nanaocha, Sharma |
| Rok vydání: |
2021 |
| Zdroj: |
Frontiers in pharmacology. 13 |
| ISSN: |
1663-9812 |
| Popis: |
SARS-CoV-2 is the virus responsible for causing COVID-19 disease in humans, creating the recent pandemic across the world, where lower production of Type I Interferon (IFN-I) is associated with the deadly form of the disease. Membrane protein or SARS-CoV-2 M proteins are known to be the major reason behind the lower production of human IFN-I by suppressing the expression of IFNβ and Interferon Stimulated Genes. In this study, 7,832 compounds from 32 medicinal plants of India possessing traditional knowledge linkage with pneumonia-like disease treatment, were screened against the Homology-Modelled structure of SARS-CoV-2 M protein with the objective of identifying some active phytochemicals as inhibitors. The entire study was carried out using different modules of Schrodinger Suite 2020-3. During the docking of the phytochemicals against the SARS-CoV-2 M protein, a compound, ZIN1722 from |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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