| Autor: |
Karolin, Wagener, Dorothea, Moderegger, Mareli, Allmeroth, Achim, Reibel, Stefan, Kramer, Barbara, Biesalski, Nicole, Bausbacher, Rudolf, Zentel, Oliver, Thews, Frank, Rösch |
| Rok vydání: |
2016 |
| Předmět: |
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| Zdroj: |
Nuclear medicine and biology. 58 |
| ISSN: |
1872-9614 |
| Popis: |
For the evaluation of macromolecular drug delivery systems suitable pre-clinical monitoring of potential nanocarrier systems is needed. In this regard, both short-term as well as long-term in vivo tracking is crucial to understand structure-property relationships of polymer carrier systems and their resulting pharmacokinetic profile. Based on former studies revealing favorable in vivo characteristics forIn this respect, four different HPMA-based polymers (homopolymers as well as random copolymers with LMA as hydrophobic segment) were synthesized and subsequent radioactive labeling was accomplished via the longer-lived radioisotopeStudies revealed, at first, differences in the short time (2h) body distribution, despite the very similar properties (molecular structure, CMC and size of the micellar aggregates) of the non-radioactiveThe observed in vivo characteristics strongly underline the EPR effect. The findings illustrate the need to combine information of different labeling approaches and in vivo evaluation techniques to generate an overall pharmacokinetic picture of potential nanocarriers in the pre-clinical setting.The in vivo behavior of the investigated HPMA-ran-LMA copolymer demonstrates great potential in terms of an effective accumulation in the tumor. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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