[A comparative evaluation of the immunological efficacy of ADPT vaccine and ADT-M anatoxin in the immunization of children against diphtheria and tetanus]
| Autor: | E V, Rusakova, M S, Bezuglova, V I, Vasil'eva, K D, Frank, G M, Panina |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Diphtheria-Tetanus Vaccine
Tetanus Diphtheria Toxoid Corynebacterium diphtheriae Immunization Secondary Infant Diphtheria Hemagglutination Tests Antibodies Bacterial Drug Combinations Child Preschool Clostridium tetani Tetanus Toxoid Drug Evaluation Humans Immunization Child Diphtheria-Tetanus-Pertussis Vaccine |
| Zdroj: | Zhurnal mikrobiologii, epidemiologii i immunobiologii. (7) |
| ISSN: | 0372-9311 |
| Popis: | Comparative study of the immunological effectiveness of adsorbed diphtheria-pertussis-tetanus (DPT) vaccine and adsorbed diphtheria-tetanus toxoid with reduced antigen content (adsorbed DT toxoid R) in the immunization of children, carried out in accordance with the vaccination schedule, was made. Immune response to the injection of adsorbed DPT vaccine was higher than after immunization with adsorbed DT toxoid R, as evidenced by antibody titers. It was probably due to differences in the number of injections constituting the course of immunization: it consisted of 3 injections and 1 booster injection for adsorbed DPT vaccine and 2 injections and 1 booster injection for adsorbed DT toxoid R. Immunization with adsorbed DPT vaccine produced immunity which was retained for a longer period. These results are indicative of the expediency of the primary immunization of children with adsorbed DT toxoid R introduced in three injections in order to ensure more stable and prolonged postvaccinal (mainly antidiphtheria) immunity. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|