[Immune response to the oral administration of a new meningococcal preparation, serogroup A, under experiment]
| Autor: | N N, Aleksakhina, I A, Basnak'ian, N N, Kozlova |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Lipopolysaccharides
Time Factors Vaccination Dose-Response Relationship Immunologic Administration Oral Hemagglutination Tests Antibodies Bacterial Immunoenzyme Techniques Meningococcal Infections Disease Models Animal Mice Neisseria meningitidis Serogroup A Polysaccharides Immunoglobulin G Animals Rabbits Bacterial Outer Membrane Proteins |
| Zdroj: | Zhurnal mikrobiologii, epidemiologii i immunobiologii. (3) |
| ISSN: | 0372-9311 |
| Popis: | In the experiment on rabbits immune response to the oral administration of a new Neisseria meningitidis whole culture preparation, serogroup A, was demonstrated. The preparation was based on the acetone fixed culture, grown by the continuous flow method under a computer-controlled constant level of oxygen. The immunological activity of the preparation was demonstrated. In the blood sera of rabbits examined by immunoenzyme assay and the passive hemagglutination test, a multiple increase in the content of hemagglutinating and IgG antibodies to polysaccharide, outer membrane proteins and lipooligosaccharide was noted, their content remaining at a high level for 303 days (the term of observation). The oral immunization with the preparation protected mice infected with N. meningitidis live culture, serogroup A. |
| Databáze: | OpenAIRE |
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