| Popis: |
Background: Intensive care practice calls for ventilator adjustments due to fast-changing clinical conditions in ventilated critically ill children. These adaptations include positive end-expiratory pressure (PEEP), fraction of inspired oxygen (FiO(2)), and respiratory rate (RR). It is unclear which alterations in ventilator settings trigger a significant systemic inflammatory response. Methods: Fourteen-day old Wistar rat pups were randomized to the following groups: (a) “control” with tidal volume ~8 mL/kg, PEEP 5 cmH(2)O, FiO(2) 0.4, RR 90 min(-1), (b) “PEEP 1”, (c) “PEEP 9” (d) “FiO(2) 0.21”, (e) “FiO(2) 1.0”, (f) “hypocapnia” with RR of 180 min(-1), and (g) “hypercapnia” with RR of 60 min(-1). Following 120 min of mechanical ventilation, plasma for inflammatory biomarker analyses was obtained by direct cardiac puncture at the end of the experiment. Results: Interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) were driven by FiO(2) 0.4 and 1.0 (P=0.02, P |
