| Autor: |
Bui Q, Phuc, Sonia R, Caruana, Alan F, Cowman, Beverley-Ann, Biggs, Ngo V, Thanh, Nong T, Tien, Le K, Thuan |
| Rok vydání: |
2008 |
| Předmět: |
|
| Zdroj: |
The Southeast Asian journal of tropical medicine and public health. 39(6) |
| ISSN: |
0125-1562 |
| Popis: |
In 2002 an antimalarial drug resistance survey was carried out in a seasonally endemic area of Vietnam. Sulfadoxine/pyrimethamine (S/P) was the standard treatment recommended for uncomplicated Plasmodium falciparum malaria in that area at the time. Early or late treatment failure as defined by WHO was observed in 14.9% (7/47) of patients. Molecular analysis of treatment failure isolates identified that 5/6 carried two or more dhfr and dhps polymorphisms associated with S/P resistance. Chloroquine resistance-associated polymorphisms occurred in 38.5% (15/39) of the isolates. These results support the move to artemisinin-based combination therapy for malaria in Vietnam. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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