IFN-alpha super-induction of HLA class I expression by a variant thymoma cell line involves nuclear translocation of Rel complexes

Autor:	H, Travers, J, Girdlestone
Rok vydání:	1998
Předmět:	Cell Nucleus Thymoma Histocompatibility Antigens Class I NF-kappa B Interferon-alpha Biological Transport Proto-Oncogene Proteins c-rel DNA-Binding Proteins Ligases NF-KappaB Inhibitor alpha Proto-Oncogene Proteins Tumor Cells Cultured Humans I-kappa B Proteins
Zdroj:	European journal of immunology. 28(11)
ISSN:	0014-2980
Popis:	Variant thymoma lines have been described which exhibit a substantially increased level of HLA class I induction by IFN-alpha, but not by IFN-gamma, and an unchanged response of other IFN-alpha-stimulated genes (Burrone et al., EMBO J. 1985. 4: 2855-2860). We report that their amplified response correlates with the nuclear translocation of Rel transcription factors upon prolonged treatment with IFN-alpha. The variant cells contain an IkappaBalpha subset with a significantly shortened half-life, and a constitutively active form of IkappaBalpha efficiently blocks HLA class I induction. Therefore, in addition to STAT-mediated induction, prolonged exposure to IFN-alpha can affect transcription involving Rel factors, which are implicated in the regulation of numerous immune response and viral genes.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::1243fc0ff0affc048574a480f5466c86 https://pubmed.ncbi.nlm.nih.gov/9842922 Zobrazit plný text záznamu Plný text