| Autor: |
C, Fan, P O, Nylander, U, Stendahl, M, Thunell, L, Beckman |
| Rok vydání: |
1995 |
| Předmět: |
|
| Zdroj: |
Experimental and clinical immunogenetics. 12(2) |
| ISSN: |
0254-9670 |
| Popis: |
In previous studies of orosomucoid (ORM) types and disease the ORM1 1 type has been found to be associated with sarcoidosis and other immunogenetic diseases, and the ORM 1 2 type with different types of carcinomas. We report significant associations between ORM1 and C3 types in sarcoidosis and breast cancer, but not in healthy individuals. The ORM1 1 and C3S variants in combination increased the risk of sarcoidosis, and the ORM1 2 and C3F variants together gave an increased risk of breast cancer. A probable mechanism may be that the ORM1 and C3 molecules modify the immune response by interacting with the lymphoid cell surface. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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