| Autor: |
Anna C, Cunha, Vitor F, Ferreira, Maria G F, Vaz, Rafael A Allão, Cassaro, Jackson A L C, Resende, Carolina Q, Sacramento, Jéssica, Costa, Juliana L, Abrantes, Thiago Moreno L, Souza, Alessandro K, Jordão |
| Rok vydání: |
2019 |
| Předmět: |
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| Zdroj: |
Molecular diversity. 25(4) |
| ISSN: |
1573-501X |
| Popis: |
HSV disease is distributed worldwide. Anti-herpesvirus drugs are a problem in clinical settings, particularly in immunocompromised individuals undergoing herpes simplex virus type 1 infection. In this work, 4-substituted-1,2,3-1H-1,2,3-triazole linked nitroxyl radical derived from TEMPOL were synthesized, and their ability to inhibit the in vitro replication of HSV-1 was evaluated. The nitroxide derivatives were characterized by infrared spectroscopy and elemental analysis, and three of them had their crystal structures determined by single-crystal X-ray diffraction. Four hybrid molecules showed important anti-HSV-1 activity with IC |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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