| Autor: |
J L, Ebersole, L, Orraca, M J, Novak, S, Kirakodu, J, Gonzalez-Martinez, O A, Gonzalez |
| Rok vydání: |
2019 |
| Předmět: |
|
| Zdroj: |
Advances in experimental medicine and biology. 1197 |
| ISSN: |
0065-2598 |
| Popis: |
Epithelial cells and functions of the epithelium are critical to the health of the oral cavity. We used a nonhuman primate model to profile the transcriptome of gingival tissues in health across the lifespan and hypothesized that in older animals, epithelial-related transcriptome patterns would reflect epithelial cells that are aggressively responsive to the surrounding environment and less able to modulate and resolve the noxious challenge from the bacteria. Rhesus monkeys (n = 34) with a healthy periodontium were distributed into four groups: ≤3 years (young), 3-7 years (adolescent), 12-16 years (adult), and 18-23 years (aged), and a buccal gingival sample from the premolar/molar region of each animal was obtained. RNA was subjected to a microarray analysis (GeneChip |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
