Prevalence and outcome of non-alcoholic fatty liver disease in adolescents and young adults undergoing weight loss surgery

Autor:	K E, Corey, T L, Stanley, J, Misdraji, C, Scirica, J, Pratt, A, Hoppin, M, Misra
Rok vydání:	2014
Předmět:	Adult Male Adolescent Bariatric Surgery digestive system Article Body Mass Index Liver Function Tests Non-alcoholic Fatty Liver Disease Risk Factors Weight Loss Prevalence Humans Transaminases Retrospective Studies Glycated Hemoglobin Sleep Apnea Obstructive nutritional and metabolic diseases digestive system diseases United States Obesity Morbid Treatment Outcome Diabetes Mellitus Type 2 Liver Disease Progression Female Insulin Resistance Biomarkers
Zdroj:	Pediatric obesity. 9(5)
ISSN:	2047-6310
Popis:	We evaluated the prevalence of non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) in 27 adolescents referred for weight loss surgery (WLS).On biopsy, 18 patients (66.7%) had NAFLD, and of those, 10 (37.0%) had NASH and 11 (40.7%) had fibrosis. Insulin, HbA1C and homeostatic model assessment of insulin resistance (HOMA-IR) were significantly higher in patients with NASH than those without NASH. Following WLS, 40% of patients with NASH had persistently elevated aminotransferase levels despite weight loss.We found that NASH is underdiagnosed in adolescents referred for WLS, and that hyperinsulinaemia, HOMA-IR and HbA1c can aid in identifying high-risk patients.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::11dc6a38e75c41dd62a58610be98b50e https://pubmed.ncbi.nlm.nih.gov/24677740 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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