| Autor: |
K, Fleischmann, K H, Scheunemann, H U, Schorlemmer, G, Dickneite, J, Blumbach, G, Fischer, W, Dürckheimer, H H, Sedlacek |
| Rok vydání: |
1989 |
| Předmět: |
|
| Zdroj: |
Arzneimittel-Forschung. 39(7) |
| ISSN: |
0004-4172 |
| Popis: |
A series of carboxyalkylthio-substituted thiazole-carboxylic acids was synthesized and examined for macrophage activation and stimulation of the DTH (delayed type of hypersensitivity)-reaction. The structure-activity relationship in this series of new immunomodulators is discussed. Broadest immunological activity was seen for [2-(3-carboxy-1-propylthio)-4-methyl-1,3-thiazole]acetic acid (tiprotimod, HBW 538) which was selected for further studies. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
