CD4

Autor: Elien M, Doorduijn, Marjolein, Sluijter, Daniela C, Salvatori, Serenella, Silvestri, Saskia, Maas, Ramon, Arens, Ferry, Ossendorp, Sjoerd H, van der Burg, Thorbald, van Hall
Rok vydání: 2016
Předmět:
Zdroj: Cancer immunology research. 5(8)
ISSN: 2326-6074
Popis: One of the next challenges in cancer immunotherapy is the resistance of tumors to T-cell-based treatments through loss of MHC class I. Here, we show that under these circumstances, the Toll-like receptor (TLR)-7/8 ligand imiquimod, but not the TLR3 ligand poly I:C or TLR9 ligand CpG, mediated an effective antitumor response. The rejection of these immune-escaped cancers was mediated by NK cells and CD4
Databáze: OpenAIRE