[The role of interleukin 1-beta in pathogenesis and treatment of recurrent suppurative rhinosinusitis]

Autor: N A, Aref'eva, L F, Aznabaeva, E R, Sharipova
Rok vydání: 2012
Předmět:
Zdroj: Vestnik otorinolaringologii. (6)
ISSN: 0042-4668
Popis: The objective of the present work was to study specific immunogenetic characteristics of 1-beta interleukin (IL 1-beta) production and estimate the possibility of using recombinant IL 1-beta for the treatment of recurrent suppurative rhinosinusitis. It was shown that the low production of IL 1-beta attributable to the combination of genotypes +3953T *C/*C and -511CT *C/*TAND *t/*t is associated with a relapse of suppurative rhinosinusitis. The patients presenting with this disorder are in need of dispensary examination and repeated administration of recombinant IL 1 beta (betaleukin) during the period of exacerbation of suppurative rhinosinusitis.
Databáze: OpenAIRE