| Autor: |
K, Ohno, W R, Fredericks, S I, Rapoport |
| Rok vydání: |
1979 |
| Předmět: |
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| Zdroj: |
Surgical neurology. 12(4) |
| ISSN: |
0090-3019 |
| Popis: |
Osmotic opening of the blood-brain barrier in the rat, by intracarotid infusion of 1.6 molal (m) arabinose solution, increases cerebrovascular permeability to 3H-methotrexate by a factor of about seven. PA (product of permeability and capillary surface area) increases from a mean of 3.3 X 10(-5) sec-1 in brains of control rats to as much as 28 X 10(-5) sec-1 at the cerebral hemisphere ipsilateral to carotid infusion. If tracer is introduced into the carotid artery after osmotic treatment, brain uptake is increased by a net factor of 50 (a factor of 70 due to elevation of PA, multiplied by 7 due to infusion by the carotid route) as compared to uptake by normal, untreated brain with infusion into a peripheral vein. Osmotic barrier opening followed by carotid drug administration may be of use in experimental chemotherapy of nervous system disease. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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