| Autor: |
Masoud, Eskandani, Morteza, Eskandani, Somayeh, Vandghanooni, Bahman, Navidshad, Farzad Mirzaei, Aghjehgheshlagh, Ali, Nobakht |
| Rok vydání: |
2021 |
| Předmět: |
|
| Zdroj: |
Colloids and surfaces. B, Biointerfaces. 212 |
| ISSN: |
1873-4367 |
| Popis: |
L-carnitine (LC) is a highly water-soluble compound involved in the β-oxidation of lipids and transportation of long-chain fatty acids across the membrane of mitochondria. However, the higher hydrophilicity of LC limits its free diffusion across the bilayer lipid membrane of intestinal epithelium in oral administration, decreasing oral bioavailability. Drug delivery with nanoparticles enhances cargo bioavailability and cellular uptake and improves therapeutic outcomes while decreasing unwanted side effects. Here, we proposed solid lipid nanoparticles (SLNs) as a hydrophobic carrier for LC delivery, aiming at increasing LC bioavailability and its protective role against intracellular oxidative stress damages. The LC-SLNs were prepared using the hot homogenization technique, and different physicochemical properties were investigated. The inhibition of H |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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