| Autor: |
L, Dillner, A, Zellbi, E, Avall-Lundqvist, P, Heino, C, Eklund, C A, Pettersson, O, Forslund, B G, Hansson, M, Grandien, P, Bistoletti |
| Rok vydání: |
1995 |
| Předmět: |
|
| Zdroj: |
Cancer detection and prevention. 19(5) |
| ISSN: |
0361-090X |
| Popis: |
In order to provide a large-scale evaluation of the association with cervical cancer of antibodies against human papillomavirus (HPV) antigens, sera from 233 patients with primary, untreated cervical cancer and from 157 healthy age- and sex-matched blood donors were analyzed for IgG and IgA antibodies against HPV-derived peptide antigens and against bovine papillomavirus. Several serological responses were strongly associated with cervical cancer, notably the IgG response against the HPV 16 epitopes L1:13 (Relative risk [RR]: 5.3), E2:9 (RR: 2.9), and E7:5 (RR: 4.3), and the IgA response against an HPV 18 E2-derived antigen (245:18, RR: 3.1). HPV DNA in corresponding cervical tumors was analyzed by Southern blotting (SB) and polymerase chain reaction (PCR) in 47 patients. Sixty-six percent of the patients carried HPV DNA as determined by SB, 91% of patients analyzed by PCR. Neither the antibody responses, nor the presence of HPV DNA were significantly associated with the biological properties of the tumors. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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