Cytokine and adhesion molecule requirements for lung injury induced by anti-glomerular basement membrane antibody
| Autor: | M S, Mulligan, A B, Lentsch, T P, Shanley, M, Miyasaka, K J, Johnson, P A, Ward |
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| Rok vydání: | 1998 |
| Předmět: |
Male
Integrins Anti-Glomerular Basement Membrane Disease Neutrophils Kidney Glomerulus Receptors Lymphocyte Homing Macrophage-1 Antigen Integrin alpha4beta1 Antibodies Basement Membrane Animals Humans L-Selectin Antibodies Blocking Lung Sheep Tumor Necrosis Factor-alpha Antibodies Monoclonal Complement System Proteins Lung Injury Lymphocyte Function-Associated Antigen-1 Rats Disease Models Animal Immunoglobulin G Cytokines Cell Adhesion Molecules Interleukin-1 |
| Zdroj: | Inflammation. 22(4) |
| ISSN: | 0360-3997 |
| Popis: | Acute hemorrhagic lung injury occurs in humans with anti-GBM antibody (Goodpasture's syndrome), however, the mechanism of this injury is still largely unknown. To date, treatment has been confined to steroids and plasmaphoresis. Infusion of anti-GBM antibody into rats caused lung injury with intra-alveolar hemorrhage and intrapulmonary accumulation of neutrophils. Lung injury was dependent on the presence of neutrophils and complement and required both TNF alpha and IL-1. Experiments employing blocking antibodies to adhesion molecules demonstrated requirements for the beta 1 integrin VLA-4, beta 2 integrins LFA-1 and Mac-1, and L-selection. The endothelial cell adhesion molecules, E-selectin and ICAM-1, were also required for the full development of lung injury. Inhibition of TNF alpha or IL-1 or adhesion molecules reduced both lung injury and tissue neutrophil accumulation. Thus, this study underscores cytokine and adhesion molecule requirements for neutrophil mediated injury in lung and kidney caused by anti-GBM, suggesting potential targets for the treatment of Goodpasture's syndrome in humans. |
| Databáze: | OpenAIRE |
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