Effect of oral diuretics on pulmonary mechanics in infants with chronic bronchopulmonary dysplasia: results of a double-blind crossover sequential trial
| Autor: | L C, Kao, D, Warburton, M H, Cheng, C, Cedeño, A C, Platzker, T G, Keens |
|---|---|
| Rok vydání: | 1984 |
| Předmět: |
Clinical Trials as Topic
Time Factors Airway Resistance Body Weight Osmolar Concentration Infant Newborn Oxygen Inhalation Therapy Administration Oral Phosphorus Infant Premature Diseases Chlorothiazide Spironolactone Random Allocation Double-Blind Method Potassium Humans Drug Therapy Combination Lung Bronchopulmonary Dysplasia |
| Zdroj: | Pediatrics. 74(1) |
| ISSN: | 0031-4005 |
| Popis: | In a randomized double-blind crossover trial with sequential analysis, the effects of oral diuretics were compared with the effects of placebo on pulmonary mechanics in ten infants with bronchopulmonary dysplasia (BPD). Pulmonary mechanics were measured before and at the end of a week of treatment with oral diuretics (chlorothiazide, 20 mg/kg/dose and spironolactone, 1.5 mg/kg/dose) given twice daily, or placebo. Mean airway resistance decreased 35.3 cm H2O/L/s, mean specific airway conductance increased 0.095 1/L/s/cm H2O, and mean dynamic pulmonary compliance increased 1.74 mL/cm H2O during treatment with diuretics (all P less than .001), but not during treatment with placebo. The infants' rate of weight gain decreased on the first three days of diuretic treatment, but was thereafter comparable with weight gain during treatment with placebo. Fluid intake was similar in infants receiving diuretics and placebo. But, infants receiving diuretics not only had significantly increased urine output, osmolal clearance, and potassium and phosphorus excretion, but these infants also retained less fluid, and, in addition, excreted less calcium than infants receiving placebo. It is concluded that oral diuretics improve lung function in infants with chronic bronchopulmonary dysplasia; however, potassium and phosphorus depletion are potential complications of treatment. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|