[The effect of antihistaminic preparations on the binding of labelled mepyramine, ketanserin and quinuclidinyl benzilate in the rat brain]

Autor:	E M, Gankina, N V, Porodenko, T I, Kondratenko, E S, Severin, M E, Kaminka, M D, Mashkovskiĭ
Rok vydání:	1993
Předmět:	Male Pyrilamine Brain Ligands Tritium Receptors Muscarinic Rats Quinuclidinyl Benzilate Rats Sprague-Dawley Histamine H2 Antagonists Histamine H1 Antagonists Animals Drug Interactions Receptors Histamine H2 Ketanserin Receptors Histamine H1
Zdroj:	Eksperimental'naia i klinicheskaia farmakologiia. 56(1)
ISSN:	0869-2092
Popis:	The effects of some antiallergic drugs on H1-histamine, 5-HT2-serotonin, and M-cholinoreceptors ligand binding in the rat brain were studied in vitro. Dimedrol, dimebon, and phencarol bonded to H1-receptors: IC50 were 76 +/- 10, 153 +/- 15, 320 +/- 60 nM, respectively. Diazoline and dimebon had some affinity for 5-HT2-receptors, its IC50 was 880 +/- 90 nM. Dimedrol, phencarol and diazoline were found to be active against M-cholinoceptors, but when given in the maximal concentration (10 microM) it acted nonspecifically. In contrast to the other drugs, bicarphen had no effects on the binding of [3H]-mepyramine, [3H]-ketanserine, and [3H]-quinuclidinyl benzylate in the rat brain.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::10b9106637dbe309514994720772dae8 https://pubmed.ncbi.nlm.nih.gov/8100727 Zobrazit plný text záznamu