FEV
| Autor: | Helena, Backman, Anne, Lindberg, Linnea, Hedman, Caroline, Stridsman, Sven-Arne, Jansson, Thomas, Sandström, Bo, Lundbäck, Eva, Rönmark |
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| Rok vydání: | 2019 |
| Předmět: |
FVC
Forced Expiratory Volume Neutrophils N Number EOS Eosinophils BMI Body mass index ATS American Thoracic Society L Liters Article GLI Global Lung function Initiative FEV1 Forced Expiratory Volume in 1 s ICS Inhaled corticosteroids FEV1 OLS Ordinary Least Squares Ml Milliliters OLIN Obstructive Lung Disease in Northern Sweden Cohort respiratory system VGDF Vapors gas dust or fumes ECRHS European Community Respiratory Health Survey Asthma ERS European Respiratory Society respiratory tract diseases Eosinophils FEV1pp FEV1 percent of predicted IgE Immunoglobulin E NEU Neutrophils ANOVA Analysis of variance OCS Oral corticosteroids |
| Zdroj: | The World Allergy Organization Journal |
| ISSN: | 1939-4551 |
| Popis: | Background The relationship between lung function decline and eosinophils and neutrophils has important therapeutic implications among asthmatics, but it has rarely been studied in large cohort studies. Objective The aim is to study the relationship between blood eosinophils and neutrophils and FEV1 decline in a long-term follow-up of a population-based adult asthma cohort. Methods In 2012–2014, an adult asthma cohort was invited to a follow-up including spirometry, blood sampling, and structured interviews, and n = 892 participated (55% women, mean age 59 y, 32–92 y). Blood eosinophils, neutrophils and FEV 1 decline were analyzed both as continuous variables and divided into categories with different cut-offs. Regression models adjusted for smoking, exposure to vapors, gas, dust, or fumes (VGDF), use of inhaled and oral corticosteroids, and other possible confounders were utilized to analyze the relationship between eosinophils and neutrophils at follow-up and FEV1 decline. Results The mean follow-up time was 18 years, and the mean FEV 1 decline was 27 ml/year. The annual FEV1 decline was related to higher levels of both blood eosinophils and neutrophils at follow-up, but only the association with eosinophils remained when adjusted for confounders. Further, the association between FEV1 decline and eosinophils was stronger among those using ICS. With EOS |
| Databáze: | OpenAIRE |
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