| Autor: |
O B, Flekhter, L T, Karachurina, V V, Poroĭkov, L R, Nigmatullina, L A, Baltina, F S, Zarudiĭ, V A, Davydova, L V, Spirikhin, I P, Baĭkova, F Z, Galin, G A, Tolstikov |
| Rok vydání: |
2000 |
| Předmět: |
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| Zdroj: |
Bioorganicheskaia khimiia. 26(3) |
| ISSN: |
0132-3423 |
| Popis: |
Hemisuccinates, hemiphthalates, acetylsalicylates, cinnamates, and p-methoxycinnamates of lupeol, betulin, and 3-O-acetylbetulin were synthesized via interaction with corresponding acid anhydrides or acid chlorides. A number of betulin esters in position 3 and 28 were shown to exhibit a pronounced hepatoprotective effect similar to that of betulin and silibor. These experimental data were in a good agreement with the computer prediction of their biological activity. Betulin 3,28-bis-hemiphthalate was more effective than carsil in models of experimental hepatitis caused by carbon tetrachloride, tetracycline, and ethanol. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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