| Autor: |
Galescu, Ovidiu A., Crocker, Melissa K., Altschul, Anne M., Marwitz, Shannon E., Brady, Sheila M., Yanovski, Jack A. |
| Jazyk: |
angličtina |
| Rok vydání: |
2016 |
| Předmět: |
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| Popis: |
Children with obesity have low spontaneous growth hormone (GH) secretion. High circulating free fatty acid (FFA) concentration is believed to inhibit GH secretion in those with obesity. In adults, lipolytic inhibition with niacin lowers FFA and increases GH, but there are no prior studies in children with obesity.The objective of the study was to determine the dose and frequency of niacin administration required to lower FFA and stimulate GH in children with obesity.Dose-finding study of nondiabetic children ages 6-12 years with body mass index (BMI) ≥ 95th percentile given niacin 250 mg q2h × 3 doses (n = 2), 500 mg q2h × 3 doses (n = 5) or 500 mg q1h × 4 doses (n = 5).Eight boys and four girls (age 9.7 ± 1.8 years; BMI 26.4 ± 3.1 kg mPercentage of serum FFA values that were below 0.2 mEq LFFA decreased as the dose and frequency of niacin increased (p = .01). Niacin 500 mg q1h 4 doses suppressed FFA 0.2 mEq LNiacin 500 mg q1h significantly lowered serum FFA and increased GH. These pilot data suggest that high FFA is an important suppressor of GH secretion in children with obesity. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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