| Autor: |
A, Rojas-Martínez, M C, Villalobos-Torres, R I, Ortiz-de-Luna, M T, Pompa-Garza, H A, Barrera-Saldaña |
| Rok vydání: |
1996 |
| Předmět: |
|
| Zdroj: |
Revista de investigacion clinica; organo del Hospital de Enfermedades de la Nutricion. 48(2) |
| ISSN: |
0034-8376 |
| Popis: |
The genomic DNAs of carrier mothers from 20 hemophilia A unrelated Mexican families were analysed by polymerase chain reaction (PCR) amplification of the Bcl I polymorphic region at intron 18 of the factor VIII gene. Eleven women (55%) were found to be informative (Bcl I+/Bcl I-), eight (40%) were Bcl I- homozygotes and one (5%) was a Bcl I+ homozygote. In 18 daughters of the informative families we were able to establish carrier status for eight. The frequency of the Bcl I alleles in the 20 mothers was 0.675 for Bcl I- and 0.325 for Bcl I+ which give a frequency of 44% of heterozygous females in our sample. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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