[Predictive value of the assay of serum anti-p25 antibodies in patients with human immunodeficiency virus (HIV-1) infection]
| Autor: | E, Fenouillet, N, Blanes, A, Coutellier, J, Demarquest, W, Rozenbaum, J C, Gluckman |
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| Jazyk: | francouzština |
| Rok vydání: | 1993 |
| Předmět: |
Adult
Male Acquired Immunodeficiency Syndrome Time Factors Radioimmunoassay Gene Products gag Enzyme-Linked Immunosorbent Assay HIV Infections HIV Antibodies gag Gene Products Human Immunodeficiency Virus Predictive Value of Tests HIV-1 Humans Female Longitudinal Studies Follow-Up Studies Retrospective Studies |
| Zdroj: | Annales de medecine interne. 144(5) |
| ISSN: | 0003-410X |
| Popis: | To assess whether monitoring of antibodies (Ab) directed against the HIV-1 p25 core protein may be used as a predictive marker in the biological monitoring of HIV-infected patients, a study was performed on a transversal cohort of 68 CDC stage II-III, and 36 ARC and 26 AIDS stage IV patients, 37 of whom were being treated with anti-retroviral therapy. A second cohort included 56 patients followed for 3-7 years: 15 stage II-III, 11 ARC and 30 AIDS patients (opportunistic infections: 14; Kaposi's sarcoma: 11; non-Hodgkin's lymphoma: 5). p25 antigenemia and CD4+ blood lymphocyte counts were determined in parallel. Stage II-III patients usually had high and stable anti-p25 Ab levels, ARC patients exhibited more heterogeneous Ab values, while those with AIDS had very low values. No significant difference was observed in the serum anti-p25 levels of patients treated or not with anti-retroviral therapy. In patients whose CD4(+)-cell counts were going to fall below 200/mm3 and/or who were going to progress towards AIDS, the Ab levels started to decrease at a rate of1 log U/ml (expressed in arbitrary units/ml) per 5 years at least 2 to 4 years, respectively, before the appearance of the index symptom, despite the fact that the CD4(+)-cell count only differed significantly between progressors and non-progressors one year before the appearance of the disease.(ABSTRACT TRUNCATED AT 250 WORDS) |
| Databáze: | OpenAIRE |
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