In vitro concentration response studies and in vitro phase II tests as the experimental basis for regional chemotherapeutic protocols

Autor:	K H, Link, G, Leder, J, Pillasch, U, Butzer, L, Staib, M, Kornmann, U, Bruckner, H G, Beger
Rok vydání:	1998
Předmět:	Time Factors Dose-Response Relationship Drug Chemotherapy Cancer Regional Perfusion Liver Neoplasms Tumor Cells Cultured Humans Infusions Intra-Arterial Antineoplastic Agents Chemoembolization Therapeutic Drug Screening Assays Antitumor In Vitro Techniques
Zdroj:	Seminars in surgical oncology. 14(3)
ISSN:	8756-0437
Popis:	The theoretical pharmacologic benefit of regional vs. systemic chemotherapy is defined and the concentration response behavior of cytostatic drugs and their optimal exposure times are described with human cancer cell lines (HT29, NMG64/84) and fresh human tumor cell suspensions in the human tumor colony assay (HTCA). The theoretical pharmacological advantages are 5.8 to 6 for adriamycin (ADM), 8 for cisplatinum (CDDP), 6.3 for epidoxorubicin (EPI), 22 to 58 for 5-fluorouracil (5FU), 4.6 for mitomycin C (MMC), and 6.3 for mitoxantrone (NOV). The drugs differed in their cytotoxic potency in vitro and thus also potential efficacy for regional chemotherapy; however, all but 5-fluorodeoxyuridine (5FUDR) exerted cytotoxicity dependent on exposure time and concentration. On average, elevation of the test concentrations by 1 lg doubled responses in fresh human tumor cell suspensions. From these results and clinical considerations, optimal times were defined for the regional chemotherapy strategies of hepatic artery infusion, intraperitoneal instillation, and chemoembolisation as performed at our institution.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::1020d624c5d4098e95a001b429257ade https://pubmed.ncbi.nlm.nih.gov/9548601 Zobrazit plný text záznamu Plný text