The l,d-Transpeptidase Ldt
| Autor: | Marta, Toth, Nichole K, Stewart, Clyde A, Smith, Mijoon, Lee, Sergei B, Vakulenko |
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| Rok vydání: | 2023 |
| Předmět: | |
| Zdroj: | ACS infectious diseases. 8(9) |
| ISSN: | 2373-8227 |
| Popis: | l,d-Transpeptidases (LDTs) are enzymes that catalyze reactions essential for biogenesis of the bacterial cell wall, including formation of 3-3 cross-linked peptidoglycan. Unlike the historically well-known bacterial transpeptidases, the penicillin-binding proteins (PBPs), LDTs are resistant to inhibition by the majority of β-lactam antibiotics, with the exception of carbapenems and penems, allowing bacteria to survive in the presence of these drugs. Here we report characterization of Ldt |
| Databáze: | OpenAIRE |
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