Beta-subunit of bovine rod photoreceptor cGMP phosphodiesterase. Comparison with the phosphodiesterase family
| Autor: | V M, Lipkin, N V, Khramtsov, I A, Vasilevskaya, N V, Atabekova, K G, Muradov, V V, Gubanov, T, Li, J P, Johnston, K J, Volpp, M L, Applebury |
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| Rok vydání: | 1990 |
| Předmět: |
Base Sequence
Macromolecular Substances Phosphoric Diester Hydrolases Molecular Sequence Data Restriction Mapping DNA Rod Cell Outer Segment Molecular Weight 3' 5'-Cyclic-GMP Phosphodiesterases Multigene Family Sequence Homology Nucleic Acid Animals Cattle Photoreceptor Cells Amino Acid Sequence Oligonucleotide Probes Gene Library |
| Zdroj: | The Journal of biological chemistry. 265(22) |
| ISSN: | 0021-9258 |
| Popis: | A group of cDNA clones encoding the beta-subunit of bovine rod photoreceptor cGMP phosphodiesterase were isolated for structural analysis. The encoded polypeptide has 853 residues with a calculated molecular mass of 98 kDa. The beta-subunit is 72% identical to the rod cGMP phosphodiesterase alpha-subunit. Like the alpha-subunit and the cone alpha'-subunit, the beta-subunit belongs to the family of phosphodiesterase genes. The beta- and alpha-subunits are more similar to each other than either is to the cone alpha'-subunit, suggesting either that the beta- and alpha-subunits diverged more recently or that their divergence was restrained by the rod functional environment. |
| Databáze: | OpenAIRE |
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