Antitumor agents 200. Cytotoxicity of naturally occurring resveratrol oligomers and their acetate derivatives

Autor:	M, Ohyama, T, Tanaka, T, Ito, M, Iinuma, K F, Bastow, K H, Lee
Rok vydání:	1999
Předmět:	Biopolymers Resveratrol Stilbenes Tumor Cells Cultured Humans Acetates Drug Screening Assays Antitumor Cell Division
Zdroj:	Bioorganicmedicinal chemistry letters. 9(20)
ISSN:	0960-894X
Popis:	Eleven resveratrol oligomers and six acetylated derivatives were evaluated for in vitro cytotoxicity against a panel of human tumor cell lines. The acetate of (-)-ampelopsin A (12) showed potent and selective cytotoxic activity with ED50 values of 0.6, 0.7 and 2.0 microg/mL against KB, 1A9 and MCF-7 cells, respectively. Hopeaphenol (10) and pallidol hexaacetate (13) also showed significant cytotoxicity against KB cells with ED50 values of 1.2 and 1.6 microg/mL, respectively.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::1007069831c9f08597e69c7741f6e6cb https://pubmed.ncbi.nlm.nih.gov/10571175 Zobrazit plný text záznamu Full Text from ScienceDirect