Further structural analysis of GnRH complexes with metal ions

Autor: Kazuhiko, Nakamura, Masato, Kodaka, Ibrahim M, El-Mehasseb, Alina, Gajewska, Hiroaki, Okuno, Ewa, Ochwanowska, Bozena, Witek, Henryk, Kozłowski, Kazimierz, Kochman
Rok vydání: 2005
Předmět:
Zdroj: Neuro endocrinology letters. 26(3)
ISSN: 0172-780X
Popis: MALDI-TOF mass spectrometry, 1H NMR spectrometry, the continuous variation method and molecular modeling by MM3 calculation confirmed our earlier studies showing that gonadotropin-releasing hormone (GnRH) forms complex with copper(II) ion with the binding ratio 1:1. The copper(II) complex formed at physiological pH has a square planar configuration and GnRH complexes with nickel(II) and cobalt(II) ions are less stable than that of copper(II).
Databáze: OpenAIRE